发明名称 |
Nanoparticulate and controlled release compositions comprising cyclosporine |
摘要 |
The present invention is directed to a composition comprising a nanoparticulate cyclosporine having improved bioavailability. The nanoparticulate cyclosporine particles of the composition have an effective average particle size of less than about 2000 nm in diameter and are useful in the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases. The invention also relates to a controlled release composition comprising a cyclosporine or a nanoparticulate cyclosporine that in operation delivers the drug in a pulsed or bimodal manner for the prevention and treatment of organ transplant rejection and autoimmune diseases such as psoriasis, rheumatoid arthritis, and other related diseases. |
申请公布号 |
ZA200708260(B) |
申请公布日期 |
2010.05.26 |
申请号 |
ZA20070008260 |
申请日期 |
2007.09.27 |
申请人 |
ELAN PHARMA INTERNATIONAL LIMITED |
发明人 |
JENKINS, SCOTT;LIVERSIDGE, GARY |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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