Fusion proteins comprising CD4 minimal modules and methods of use thereof
摘要
Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
申请公布号
ZA200610232(B)
申请公布日期
2010.05.26
申请号
ZA20060010232
申请日期
2006.12.06
申请人
NOVARTIS VACCINES AND DIAGNOSTICS INC.
发明人
MASIGNANI, VEGA;CAPECCHI, BARBARA;BARNETT, SUSAN W.;RAPPUOLI, RINO;SCARSELLI, MARIA;SHARMA, VICTORIA;SRIVASTAVA, INDRESH K.