发明名称 |
COMPOSITIONS AND METHODS FOR TREATING MACULAR DEGENERATION |
摘要 |
<p>Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid in an amount sufficient to reduce accumulation of a lipofuscin pigment in the retina. Further provided are methods of retarding formation of A2E and/or ATR-dimer by replacing an all-frans-retinal (ATR) substrate with a C20-D3-retinal substrate under conditions sufficient to impede the formation of A2E. Compositions for retarding formation of a lipofuscin pigment in the retina containing a substituted C20-retinoid and a pharmaceutically acceptable carrier are also provided.</p> |
申请公布号 |
EP2187880(A1) |
申请公布日期 |
2010.05.26 |
申请号 |
EP20080830106 |
申请日期 |
2008.09.12 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
WASHINGTON, ILYAS |
分类号 |
A61K31/135 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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