发明名称 |
Octahydro-pyrrolo[3,4-b]pyrrole N-oxides |
摘要 |
The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for making the compounds, salts, and polymorphs, and methods of treating conditions and disorders using such compounds and compositions. Octahydro-pyrrolo[3,4-b]pyrrole N-oxides of formula (I) are prodrugs of histamine-3 antagonists, and are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole N-oxide compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein. |
申请公布号 |
EP2188288(A1) |
申请公布日期 |
2010.05.26 |
申请号 |
EP20080830602 |
申请日期 |
2008.09.11 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
COWART, MARLON D;MARSH, KENNAN C;LIU, HUAQING;LEE, JAE YONG;BECONI, MARIA G;WETTER, JILL M;BLACK, LAWRENCE A;CUSTER, THOMAS C;ZHAO, CHEN |
分类号 |
C07D487/04;A61K31/501;A61P25/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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