发明名称 |
N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity |
摘要 |
The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent. The invention also provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent whose side effects are made worse by increased oxidative stress or treatment related decreases in subject cysteine/glutathione levels or are otherwise relieved by administration of NAC.
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申请公布号 |
US7723389(B2) |
申请公布日期 |
2010.05.25 |
申请号 |
US20020287175 |
申请日期 |
2002.11.04 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
HERZENBERG LEONARD A.;HERZENBERG LEONORE A.;DE ROSA STEPHEN C.;ANDRUS JAMES |
分类号 |
A61K31/195;A61K31/277;A61K31/167;A61K31/198;A61K31/223;A61K31/43;A61K31/545;A61K31/60;A61K31/63;A61K31/65;A61K31/7072;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P39/00;A61P39/02;A61P43/00 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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