发明名称 |
Use of blocking anti-TSH-receptor-antibodies in the therapy of hyperthyreoses and monoclonal antibodies for a use of this type |
摘要 |
Use of blocking antibodies against the human TSH receptor (hTSH receptor) or their specifically binding fragments for the treatment of, or for preparation of drugs for the treatment of, hyperthyroidism which is attributable to stimulating autoantibodies against the hTSH receptor (Graves' disease) or overstimulation of the thyroid gland by endogenous TSH or to activating mutations of the hTSH receptor, and for the treatment of Graves' ophthalmopathy, and specific blocking monoclonal antibodies which recognize the minimum sequence FDSH corresponding to the positions 381 to 384 of the human TSH receptor.
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申请公布号 |
US7723489(B1) |
申请公布日期 |
2010.05.25 |
申请号 |
US20000889094 |
申请日期 |
2000.02.18 |
申请人 |
B.R.A.H.M.S. AKTIENGESELLSCHAFT |
发明人 |
BERGMANN ANDREAS;STRUCK JOACHIM;MORGENTHALER NILS GERNOT;JOHNSTONE ALAN P.;SHEPHERD PHILIP S. |
分类号 |
C07K16/12;A61P5/02;C07K16/28 |
主分类号 |
C07K16/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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