发明名称 |
Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37 |
摘要 |
The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.
|
申请公布号 |
US7723046(B2) |
申请公布日期 |
2010.05.25 |
申请号 |
US20070704546 |
申请日期 |
2007.02.08 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
MARUYAMA TAKAHARU;NAKAMURA TAKAO;ITADANI HARAKU;TANAKA KEN-ICHI |
分类号 |
G01N33/53;C07K14/00;C07K14/705;C12N1/21;C12N15/12 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|