发明名称 INDOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS
摘要 Disclosed are novel compounds of the formula I wherein M1 is CH or N and M2 is C(R3) or N; R1 is optionally substituted indolyl or an aza derivative thereof; R2 is optionally substituted aryl or heteroaryl; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of formula I in combination with a H1 receptor antagonist.
申请公布号 CA2489337(C) 申请公布日期 2010.05.25
申请号 CA20032489337 申请日期 2003.06.20
申请人 SCHERING CORPORATION 发明人 ASLANIAN, ROBERT G.;BERLIN, MICHAEL Y.;MANGIARACINA, PIETRO;MC CORMICK, KEVIN D.;MUTAHI, MWANGI W.;ROSENBLUM, STUART B.
分类号 C07D401/14;A61K31/445;A61K31/4545;A61K31/501;A61K31/506;A61K31/5377;A61K45/00;A61P1/00;A61P3/04;A61P9/00;A61P9/02;A61P11/00;A61P25/00;A61P25/06;A61P25/18;A61P25/20;A61P25/28;A61P27/14;A61P37/08;A61P43/00;C07D405/14;C07D409/14;C07D471/04 主分类号 C07D401/14
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