POLYMER CONJUGATES OF INTERFERON-BETA WITH ENHANCED BIOLOGICAL POTENCY

摘要

A method for increasing the biological potency of a non-glycosylated interferon-beta, comprising selectively coupling one or more synthetic water-soluble polymers to the amino-terminal amino acid of said interferon-beta, wherein said amino-terminal amino acid is located remotely from the receptor-binding domain(s) of said interferon-beta, a pharmaceutical composition comprising one or more of the conjugates. The invention further relates to a method of preventing, diagnosing, or treating an interferon-beta-responsive physical disorder.