PHARMACEUTICAL COMPOSITION CONTAINING ARYLOXYACETYL DERIVATIVES AS AN ACTIVE INGREDIENT FOR INHIBITING DNA METHYLTRANSFERASE

摘要

PURPOSE: A pharmaceutical composition containing aryloxyacetyl derivatives for suppressing DNA methyltransferase is provided to suppress DNA methylation and to use as an anti-cancer drug, therapeutic agent for neural disorder, blood dyscrasia, and epigenetic regulator. CONSTITUTION: A pharmaceutical composition for suppressing DNA methyltransferae or DNA methylation contains aryloxyacetyl derivatives of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is used for treating neural disorder caused by DNA methyltransferase suppression. The neural disorder is Rett syndrome or Angelman syndrome. The pharmaceutical composition is also used for treating blood dyscrasia such as myelodysplastic syndrome, acute myeloid leukemia, chronic myelogenous leukemia, or chronic myelomonocytic leukemia.