发明名称 |
MODIFICATION OF AMYLOID-BETA LOAD IN NON-BRAIN TISSUE |
摘要 |
The present invention relates to methods and compositions for modulating levels of amyloid-ß peptide (Aß) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of Aß levels via selective modulation (e.g., inhibition) of ?-secretase activity. The invention also relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aß-related disorder, by administering a compound that result in the modulation of ?-secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain Aß disorder, such as Alzheimer's disease. |
申请公布号 |
WO2010057020(A2) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009US64430 |
申请日期 |
2009.11.13 |
申请人 |
MODGENE, LLC;SUTCLIFFE, J. GREGOR;BLOOM, FLOYD E.;HILBUSH, BRIAN S. |
发明人 |
SUTCLIFFE, J. GREGOR;BLOOM, FLOYD E.;HILBUSH, BRIAN S. |
分类号 |
G01N33/50;A61K31/00;A61K31/506;A61P25/28 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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