CONJUGATES OF ALBUMIN BINDING DOMAIN

摘要

The invention provides a capture molecule for modulation of pharmacokinetics (PK) and/or pharmacodynamics (PD) of a target having a biological function in a mammal, comprising i) at least one target binding moiety capable of interacting with a target, said interaction being characterized by a first K0 value; ii) at least one albumin binding moiety capable of binding to albumin, said binding being characterized by a second K0 value; wherein said interaction with a target at a pH value of 5.5 modulates PK and/or PD of said target in said mammal. Also provided are methods and uses of a capture molecule for the treatment of a mammal by PK/PD modulation of a target molecule.