MELANOCORTIN RECEPTOR AGONISTS

摘要

PURPOSE: A compound having excellent activity to melanocortin is provided to apply to functional agonist of the melanocortin receptor and to prevent and treat obesity, electrile dysfunction, diabetes, or inflammation. CONSTITUTION: A composition having excellent activity to melanocortin receptor is denoted by chemical formula 1. The compound of chemical formula 1 is obtained by amide-coupling a compound of chemical formula 2 with a compound of chemical formula 3. A method for preparing the compound of chemical formula 1 comprises: a step of deprotecting a compound of chemical formula 1' or 2'; a step of performing reductive amine reaction of oxo substituent with C1-C2 alkyl, C3-C7 cycloalkyl, or heterocycle; or a step of performing coupling reaction with arylhalide or hetero arylhalide. The composition contains pharmaceutically acceptable carrier, and the compound of chemical formula 1, pharmaceutically acceptable salt, or isomer. The composition is used for treating obesity, electrile dysfunction, diabetes, or inflammation.