NOVEL HSP90-TARGETED ANTI-CANCER CHIMERIC PEPTIDE

摘要

Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or a DDS having no adverse side effect.  It is found that Hsp90 alone cannot exhibit a chaperon function that can assist the refolding of a protein such as surviving, but can exhibit the function when Hop (which is one of partner proteins of Hsp90) binds to Hsp90.  Thus, specifically disclosed is a chimeric peptide comprising an Hsp90 TPR domain binding peptide and a cell-penetrating peptide.