摘要 |
<p>The present invention relates to a compound of the formula [I]: wherein R<SUP>1 </SUP>is lower alkyl or hydroxy(lower)alkyl, and R<SUP>2 </SUP>is hydrogen or amino protecting group, or R<SUP>1 </SUP>and R<SUP>2 </SUP>are bonded together and form lower alkylene; R is -A-R<SUP>6 </SUP>wherein A is bond, -NHCO-(CH<SUB>2</SUB>CO)<SUB>n</SUB>-, lower alkylene, -NH-CO-CO- or the like, and R<SUP>6 </SUP>is wherein R<SUP>7</SUP>, R<SUP>8</SUP>, R<SUP>9 </SUP>and R<SUP>10 </SUP>are independently amino, guanidino, amidino or the like; R<SUP>4 </SUP>is carboxy or protected carboxy; and R<SUP>5 </SUP>is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.</p> |
申请人 |
ASTELLAS PHARMA INC.;WAKUNAGA PHARMACEUTICAL CO. LTD. |
发明人 |
YAMANAKA, TOSHIO;MURANO, KENJI;TODA, AYAKO;OHKI, HIDENORI;OOGAKI, MASARU;OKUDA, SHINYA;KAWABATA, KOHJI;INOUE, SATOSHI;MISUMI, KEIJI;ITOH, KENJI;SATO, KENJI |