| 摘要 |
<p>The invention comprises compounds of general formula <FORM:1003349/C2/1> wherein each X independently represents chlorine, bromine, iodine or methanesulphonyloxy; and their preparation (I) by reacting piperazine with two molecular equivalents of an appropriate pivaloyl chloride or with one molecular equivalent of two such pivaloyl chlorides in succession, (II) by halogenating or esterifying the compound where X is replaced by hydroxy. The interconversion of groups X generally is mentioned. 1,4 - Bis(acetyloxypivaloyl) piperazine is prepared from the dibromo-compound with silver acetate and is hydrolysed to 1,4-bis (hydroxypivaloyl) piperazine. Pharmaceutical compositions comprise compounds I with acceptable carriers or coatings. Forms (tablets, pills, powders, granules, syrups, elixirs, capsules, emulsions, solutions, suspensions) for oral and parenteral administration are described. The compounds act against sarcomas, carcinomas and leukaemias.</p> |
