The present invent ion also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron- sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
申请公布号
WO2010056657(A2)
申请公布日期
2010.05.20
申请号
WO2009US63852
申请日期
2009.11.10
申请人
BOARD OF REGENTS, THE UNIVESITY OF TEXAS SYSTEM;JOHNSTON, KEITH, P.;MAZUSKI, MARIA, ANDREA;ENGSTROM, JOSHUA;RODRIGUES, MIGUEL, ANGELO JOAQUIM