发明名称 |
CELL-PENETRATING, SEQUENCE-SPECIFIC AND NUCLEIC ACID-HYDROLYZING ANTIBODY, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
Disclosed are a cell-penetrating, base sequence-specific, nucleic acid-hydrolyzing antibody, a method of preparing the same, and a pharmaceutical composition comprising the same. The antibody can be prepared by modifying a particular site of a cell-penetrating, nucleic acid-hydrolyzing antibody which lacks substrate specificity to impart sequence specificity thereto without alteration in nucleic acid-hydrolyzing ability. The antibody, when penetrating into cells by itself or ectopically expressed within cells, binds specifically to single- or double-stranded nucleic acid targets and hydrolyzes them, thus downregulating the expression of the targeted genes. |
申请公布号 |
WO2010056043(A2) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009KR06628 |
申请日期 |
2009.11.11 |
申请人 |
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;KIM, YONG SUNG;KWON, MYUNG HEE;LEE, WOO RAM |
发明人 |
KIM, YONG SUNG;KWON, MYUNG HEE;LEE, WOO RAM |
分类号 |
C07K16/00;C07K16/28 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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