发明名称 |
HALOGEN-STABILIZED INSULIN |
摘要 |
<p>An insulin analogue comprises a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine or ortho-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The halogenated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Halogen substitution-based stabilization of insulin may enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration.</p> |
申请公布号 |
WO2010014946(A3) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009US52477 |
申请日期 |
2009.07.31 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY;WEISS, MICHAEL |
发明人 |
WEISS, MICHAEL |
分类号 |
C07K14/62;A61K38/28;C12N15/17 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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