NOVEL ERYTHROPOIETIN CONJUGATES BONDED WITH A BIOCOMPATIBLE POLYMER

摘要

The present invention relates to conjugates in which a non-antigenic hydrophilic biocompatible polymer is conjugated to the carboxyl group of an amino acid-containing C-terminal of erythropoietin which is a biologically active material. Said conjugates of erythropoietin and said biocompatible polymer prevent the degradation of the physiological activity of erythropoietin as much as possible, and prolong in-blood serum half-life to enhance the in vivo effects of drugs. Therefore, the conjugates of the present invention are useful for treating diseases related to erythropoiesis and hematopoiesis.