发明名称 |
SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES |
摘要 |
<p>The present invention is concerned with spiro-dihydrotetraazabenzoazulene derivatives, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene derivatives of formula (I), wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as Via receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.</p> |
申请公布号 |
WO2010054961(A1) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009EP64565 |
申请日期 |
2009.11.04 |
申请人 |
F. HOFFMANN-LA ROCHE AG;BISSANTZ, CATERINA;GOETSCHI, ERWIN;JAKOB-ROETNE, ROLAND;MASCIADRI, RAFFAELLO;PINARD, EMMANUEL;RATNI, HASANE;ROGERS-EVANS, MARK;SCHNIDER, PATRICK |
发明人 |
BISSANTZ, CATERINA;GOETSCHI, ERWIN;JAKOB-ROETNE, ROLAND;MASCIADRI, RAFFAELLO;PINARD, EMMANUEL;RATNI, HASANE;ROGERS-EVANS, MARK;SCHNIDER, PATRICK |
分类号 |
C07D487/10;A61K31/4196;A61K31/435;A61P9/00;C07D491/107;C07D495/10 |
主分类号 |
C07D487/10 |
代理机构 |
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代理人 |
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地址 |
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