| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to pharmaceutical industry. A method for preparing a pharmaceutical composition containing crystalline insulin AspB28 and dissolved insulin AspB28, protamine, Zn2+, an isotonic agent and a phenol compound by preparing an acid solution containing insulin AspB28, and an alkaline solution containing a substance which at physiological pH reacts as a buffer; at least one solution contains the phenol compound, mixed acid and alkaline solutions; the mixture is settled to form the pharmaceutical composition containing a phase with dissolved insulin AspB28 and a phase with crystallne insulin AspB28 to be added to the other phenol compound. ^ EFFECT: preparation of the pharmaceutical composition containing crystalline insulin AspB28 and dissolved insulin AspB28. ^ 3 cl, 2 ex |
