发明名称 |
BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX |
摘要 |
<p>The present application discloses novel benzimidazole derivatives of general formula (I) or an N-oxide thereof, any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Ra, Rb, and Rc independent of each other represents hydrogen or a|kyl, and Rd represents a phenyl group, which phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, alkyl, hydroxy, hydroxyalkyl and alkoxy, and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.</p> |
申请公布号 |
WO2010055126(A1) |
申请公布日期 |
2010.05.20 |
申请号 |
WO2009EP65119 |
申请日期 |
2009.11.13 |
申请人 |
NEUROSEARCH A/S;LARSEN, JANUS, S.;AHRING, PHILIP, K.;NIELSEN, ELSEBET, OESTERGAARD;MIRZA, NAHEED |
发明人 |
LARSEN, JANUS, S.;AHRING, PHILIP, K.;NIELSEN, ELSEBET, OESTERGAARD;MIRZA, NAHEED |
分类号 |
C07D401/04;A61K31/4439;A61P25/00 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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