发明名称 |
NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS |
摘要 |
The invention is concerned with the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein X, Q and R1 -R3 are defined in the detailed description and claims. The invention is also concerned with the compounds of formula Z and pharmaceutically acceptable salts and esters thereof, wherein R1-R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I and Z as well as pharmaceutical compositions containing such compounds. The compounds of formula I and Z are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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申请公布号 |
CA2739725(A1) |
申请公布日期 |
2010.05.20 |
申请号 |
CA20092739725 |
申请日期 |
2009.11.09 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
FIROOZNIA, FARIBORZ;LIN, TAI-AN;SO, SUNG-SAU;WANG, BAOXIA;YUN, HONGYING |
分类号 |
C07D213/74;A61K31/337;A61K31/4402;A61K31/505;A61P11/00;A61P11/06;A61P17/00;C07D239/42;C07D295/18;C07D295/192;C07D401/12;C07D487/10 |
主分类号 |
C07D213/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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