Chemical synthesis of phosphatidylinositol mannoside glycans form mycobacterium tuberculosis

摘要

The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM 1 , to PIM 5 ) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs linked to a carrier protein or an antigen