发明名称 |
Separation of contaminants from Streptococcus pneumoniae polysaccharide by pH manipulation |
摘要 |
A process for reducing the protein content and preserving the capsular polysaccharide content in a complex cellular Streptococcus pneumoniae lysate broth prior to purification is described. Utilizing pH reduction after cellular lysis has resulted in a purified polysaccharide that consistently meets the protein specification, and higher recovery yields of polysaccharide during the purification process.
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申请公布号 |
US7718791(B2) |
申请公布日期 |
2010.05.18 |
申请号 |
US20060396108 |
申请日期 |
2006.03.31 |
申请人 |
WYETH LLC |
发明人 |
BAHLER BRIAN;LEE TSU-SHUN;LOTVIN JASON ARNOLD;RUPPEN MARK EDWARD;CHARBONNEAU PAMELA SUE FINK |
分类号 |
C07H1/06;C07H1/00;C12P19/04 |
主分类号 |
C07H1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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