| 摘要 |
Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or absence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ether thereof; or Y is a tetrazolyl functional group; A is-(CH)-,-CHCH=CH-(CH)-, or-CHC=C-(CH)-, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is-(CH)-Ar-(CH)-wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1-CH-may be replaced by S or O, and 1-CH-CH-may be replaced by-CH=CH-or-C≡C-; Uand Uare independently selected from-H, =O,-OH,-F,-Cl, and-CN; and B is aryl or heteroaryl, for use as acular hypotensive agent. |
