发明名称 |
Polypeptides for inducing a protective immune response against Staphylococcus aureus |
摘要 |
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. MGHHHHHHHHHHSSGHIEGRHMSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKIAEQ
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申请公布号 |
US7718182(B2) |
申请公布日期 |
2010.05.18 |
申请号 |
US20060795538 |
申请日期 |
2006.01.17 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
KELLY ROSEMARIE;SCHULTZ LOREN D.;MILLER MARK A.;YEAGER MARK D.;MCNEELY TESSIE |
分类号 |
A61K39/085;C07H21/02;C07H21/04;C07K14/31;C12P21/04 |
主分类号 |
A61K39/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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