摘要 |
The present invention is directed to intraorally rapidly disintegrating tablets which, when ingested, disintegrate in the oral cavity rapidly without presenting an unpleasant taste, can be quickly absorbed in the digestive tract and express efficacy. The intraorally rapidly disintegrating tablets contain a drug being hardly water-soluble under neutral or alkaline conditions and being highly water-soluble under acidic conditions yet presenting unpleasant taste, which tablets can be prepared by combining the medicinal substance with a water-soluble acidic substance, coating either or both of the substances with a water-soluble coating agent being insoluble in alcoholic solvent, further adding a water--soluble binding agent being soluble in alcoholic solvent and a water-soluble saccharide, subjecting the resultant mixture to compression, and treating the products with an alcoholic solvent. |