NANOSTRUCTURE FOR PHOTODYNAMIC THERAPHY AND FABRICATING METHOD THEREOF

摘要

PURPOSE: A method for manufacturing a nanostructure for photodynamic therapy is provided to ensure dispersion stability and generation efficiency of singlet oxygen. CONSTITUTION: A nanostructure for photodynamic therapy contains titania(TiO_2) nanoparticles and photosensitizer adsorbed on the surface of titania nanoparticle. A polymer dispersing agent is adsorbed on the surface of titania nanoparticles. The polymer dispersing agent is selected from polymethacrylic acid sodium salt, glycol chitosan, polyvinyl alcohol, polyethyleneimine, and polyethylene glycol. The photosensitizer is a phthalocyanine derivative containing copper phthalocyanine, zinc phthalocyanine, and aluminum phthalocyanine, and a porphyrin derivative containing protoporphyrin IX, aminolevulinic acid, and hematoporphyrin. A method for manufacturing the nanostructure comprises: a step of preparing titania sol; a step of inputting polymer dispersing agent to the titania sol to adsorb on the titania surface; and a step of inputting the photosensitizer to titania sol.