BIOMARKERS IN PERIPHERAL BLOOD MONONUCLEAR CELLS FOR DIAGNOSING OR DETECTING LUNG CANCERS
摘要
<p>Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and/or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.</p>
申请公布号
WO2010054233(A1)
申请公布日期
2010.05.14
申请号
WO2009US63603
申请日期
2009.11.06
申请人
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY;SHOWE, LOUISE, C.;SHOWE, MICHAEL;KOSSENKOV, ANDREW, V.;NIKONOVA, ELENA
发明人
SHOWE, LOUISE, C.;SHOWE, MICHAEL;KOSSENKOV, ANDREW, V.;NIKONOVA, ELENA