发明名称 |
BINDING MEMBERS AGAINST IL-1R1 |
摘要 |
This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-I and IL-1Ra for binding to IL-1R1 and binds I1-1R1 with a KD of 10pM or less when measured by KinexaTM. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD). |
申请公布号 |
CA2742357(A1) |
申请公布日期 |
2010.05.14 |
申请号 |
CA20092742357 |
申请日期 |
2009.11.06 |
申请人 |
MEDIMMUNE LIMITED |
发明人 |
CAMPBELL, JAMIE IAIN;COCHRANE, DUNCAN JAMES;CRUWYS, SIMON CHARLES;FINCH, DONNA KIRSTY;GROVES, MARIA ANASTASIA TERESA;LOWE, DAVID CHRISTOPHER |
分类号 |
C07K16/28;A61K39/395;A61P11/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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