USE OF CATECHOLIC BUTANE DERIVATIVES IN CANCER THERAPY
摘要
<p>The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes can serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-IR and EGFR and comparing levels of IGF-IR and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-IR inhibitor, or both.</p>
申请公布号
WO2010054264(A1)
申请公布日期
2010.05.14
申请号
WO2009US63646
申请日期
2009.11.06
申请人
TRIACT THERAPEUTICS, INC.;WHITE, THOMAS, F.;SCHNIPPER, EDWARD, F.;HOTH, DANIEL, F.
发明人
WHITE, THOMAS, F.;SCHNIPPER, EDWARD, F.;HOTH, DANIEL, F.