FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING
摘要
<p>Vascular endothelial growth factor (VEGF) overexpression is associated with a variety of conditions involving aberrant angiogenesis. Disclosed herein are fully human antibodies that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. Based on their ability to inhibit VEGF signaling, the antibodies disclosed herein may be used to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.</p>
申请公布号
WO2008133706(A8)
申请公布日期
2010.05.14
申请号
WO2007US82164
申请日期
2007.10.22
申请人
SCHERING CORPORATION;XOMA TECHNOLOGY LTD.;RAMACHANDRA, SUMANT;BISHOP, WALTER, ROBERT;MASAT, LINDA;HUANG, CHAO BAI
发明人
RAMACHANDRA, SUMANT;BISHOP, WALTER, ROBERT;MASAT, LINDA;HUANG, CHAO BAI