SOLUBLE LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN BINDS DIRECTLY TO ALZHEIMER'S AMYLOID-BETA PEPTIDE

摘要

A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-&bgr; peptide (A&bgr;). This binding may be used to detect A&bgr; or to separate A&bgr; from the rest of a subject's body. In Alzheimer's disease, it may be used to provide diagnostic results by detecting A&bgr;, treatment by removing A&bgr;, or both.