| 摘要 |
Mimetics of nitro linoleic acid are potent agonists of PPAR-?, a receptor that regulates adipocyte differentiation, glucose homeostasis and insulin sensitivity. Thus, 10-LNO2 and 12-LN-NO2 are potent, selective activators of the PPAR-?, as are mimetics of LNO2 that bind in a manner similar to LNO2. High-resolution crystallographic data on the binding of LNO2 by PPAR-? thus inform the design of such mimetics. |
| 申请人 |
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;FREEMAN, BRUCE, A.;CHEN, YUQING, E.;XU, HUAQIANG, ERIC;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;VAN ANDEL RESEARCH INSTITUTE |
发明人 |
FREEMAN, BRUCE, A.;CHEN, YUQING, E.;XU, HUAQIANG, ERIC |
