发明名称 |
METHODS OF DETERMINING COPY NUMBER OF A GENETIC LOCUS |
摘要 |
<p>Disclosed are methods of determining in a sample, the molar ratio of a query locus to a reference locus, comprising: 1) forming one or more mixtures, each mixture comprising: a) a reference-query coupled probe comprising a nucleobase polymer comprising i) a probe reference locus comprising a probe reference allele, and ii) a probe query locus comprising a probe query allele, and b) a sample comprising i) a sample reference locus comprising a sample reference allele and ii) 0 or greater copies of a sample query locus comprising a sample query allele; 2) for each mixture, determining a) the amount of probe reference allele as a fraction of total reference allele and b) the amount of probe query allele as a fraction of total query allele; and 3) calculating the molar ratio of the sample query allele to the sample reference allele.</p> |
申请公布号 |
WO2010051464(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2009US62804 |
申请日期 |
2009.10.30 |
申请人 |
WASHINGTON UNIVERSITY;KOPAN, RAPHAEL;LIU, ZHENYI |
发明人 |
KOPAN, RAPHAEL;LIU, ZHENYI |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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