发明名称 |
OLFACTORY EPITHELIAL-DERIVED STEM CELLS AND METHODS OF USE THEREFOR |
摘要 |
<p>The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, and/or regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof.</p> |
申请公布号 |
WO2010051531(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2009US62962 |
申请日期 |
2009.11.02 |
申请人 |
UNIVERSITY OF LOUISVILLE RESERCH FOUNDATION, INC.;ROISEN, FRED, J.;LU, CHENGLIANG;WANG, MENG;QIU, MENGSHENG |
发明人 |
ROISEN, FRED, J.;LU, CHENGLIANG;WANG, MENG;QIU, MENGSHENG |
分类号 |
C12N5/079;C12N5/02 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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