发明名称 |
USE OF MICROVESICLES (MVS) DERIVED FROM STEM CELLS FOR PREPARING A MEDICAMENT FOR ENDO/EPITHELIAL REGENERATION OF DAMAGED OR INJURED TISSUES OR ORGANS, AND RELATED IN VITRO AND IN VIVO METHODS |
摘要 |
<p>The invention relates to the use of microvesicles (MVs) derived from stem cells for preparing a medicament for the endo/epithelial regeneration of damaged tissues or organs and/or for inhibiting the apoptosis induced by cytostatic agents. The stem cell from which the microvesicles are obtained is preferably selected from the group consisting of endothelial progenitor cells (EPCs), mesenchimal stem cells (MSCs), renal progenitors CDl 33+, adult human liver stem cells (HLSC) and any combination thereof. The microvesicles may be used in both in vitro and in vivo applications, such as for example the regeneration of damaged tissues or organs and the treatment of renal injury and hepatic injury, particularly acute renal failure (ARF) and acute hepatic failure (AHF).</p> |
申请公布号 |
WO2009057165(A8) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2007IT00753 |
申请日期 |
2007.10.29 |
申请人 |
FRESENIUS MEDICAL CARE DEUTSCHLAND G.M.B.H.;CANTALUPPI, VINCENZO;DEREGIBUS, MARIA CHIARA AMILDE;CAMUSSI, GIOVANNI |
发明人 |
CANTALUPPI, VINCENZO;DEREGIBUS, MARIA CHIARA AMILDE;CAMUSSI, GIOVANNI |
分类号 |
A61K35/12;A61P1/16;A61P13/12 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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