发明名称 |
A method of producing a pharmacologically stable form of lyophilised, active preparations of purified bacteriophages |
摘要 |
<p>The subject the present invention is a method of producing a pharmacologically stable form of purified and lyophilised bacteriophage preparations of increased stability and antibacterial activity, characterised in that phages produced from a bacterial lysate, for example by ultrafiltration on ultrafiltration membranes, containing a high molecular weight preparation of purified phages is stabilised most preferably with a probiotic extract in the presence or absence of neutral salts and/or organic solvents, lyophilised, characterised via HPLC chromatography, by SDS-PAGE, and bacterial lysis biological assays, and then stored under a vacuum, where the active lyophilisate is destined for phage therapy of infections and tumours.</p> |
申请公布号 |
WO2010050833(A2) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2009PL50032 |
申请日期 |
2009.10.29 |
申请人 |
INSTYTUT IMMUNOLOGII I TERAPII DOSWIADCZALNEJ POLSKIEJ AKADEMII NAUK;ZUZIAK, EWA;GAMIAN, ANDRZEJ;GORSKI, ANDRZEJ;LIPINSKI, TOMASZ |
发明人 |
ZUZIAK, EWA;GAMIAN, ANDRZEJ;GORSKI, ANDRZEJ;LIPINSKI, TOMASZ |
分类号 |
C12N7/02 |
主分类号 |
C12N7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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