COMPLEXES OF NADP WITH THE PROTEIN MABA OF MYCOBACTERIUM TUBERCULOSIS OR WITH MUTANTS THEREOF, AND THEIR USES FOR DESIGNING AND SCREENING ANTIBIOTICS

摘要

The main subject of the present invention is the use of complexes of NADP with the protein MabA, or with a derived protein, and more particularly the crystallographic coordinates of these proteins in the frame of said complexes, within the framework of the implementation of methods for designing and screening ligands of these proteins, and advantageously ligands inhibiting the enzymatic activity of these proteins, namely antibiotics capable of being used within the framework of the treatment of mycobacteriosis.