发明名称 |
COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES |
摘要 |
The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
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申请公布号 |
US2010113551(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
US20080531013 |
申请日期 |
2008.03.14 |
申请人 |
ASTEX THERAPEUTICS LIMITED;CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
WOODHEAD STEVEN JOHN;REES DAVID CHARLES;FREDERICKSON MARTYN;GRIMSHAW KYLA MERRIOM |
分类号 |
A61K31/415;C07C211/00;C07C245/00;C07D231/12;C07D303/00 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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