发明名称 |
Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics |
摘要 |
Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. An efficiency for delivering a drug cargo is provided. Compositions can include a liposome containing one or more carrier particles, each carrier particle having an active agent and a peptide, wherein the ratio of the mass of the peptide plus the mass of the liposome to the mass of the active agent is less than about 15.
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申请公布号 |
US2010112042(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
US20090580250 |
申请日期 |
2009.10.16 |
申请人 |
MDRNA, INC. |
发明人 |
POLISKY BARRY A.;ADAMI ROGER C.;TEMPLIN MICHAEL V.;HARVIE PIERROT;JOHNS RACHEL E.;GIYANANI JAYA S.;HOUSTON, JR. MICHAEL E. |
分类号 |
A61K9/127;A61K31/7088;A61K38/00;A61K38/10;A61K38/16;A61K48/00;A61P35/00;C12N15/11 |
主分类号 |
A61K9/127 |
代理机构 |
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地址 |
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