Sensor for electrophysiological investigation in living cells, comprises electrodes, which are formed in a row-or matrix arrangement on the surface of an electrically isolated substrate and are electrically isolated from one another

摘要

The sensor comprises electrodes (5), which are formed in a row-or matrix arrangement on the surface of an electrically isolated substrate (1) and are electrically isolated from one another through polymer substrate material or a polymer material subjected between the electrodes on the substrate surface. The surface of the polymer material or polymer substrate material is modified so that the surface areas (4) are equipped with increased adhesion for cells between electrodes. The additional surface areas of the polymer material are locally hydrophobized. The sensor comprises electrodes (5), which are formed in a row-or matrix arrangement on the surface of an electrically isolated substrate (1) and are electrically isolated from one another through polymer substrate material or a polymer material subjected between the electrodes on the substrate surface. The surface of the polymer material or polymer substrate material is modified so that the surface areas (4) are equipped with increased adhesion for cells between electrodes. The additional surface areas of the polymer material are locally hydrophobized. The surface is modified with carboxyl-, hydroxyl-, and/or amino groups or with fluorine compound. The electrodes and modified surface areas are arranged within a flow channel for culture medium and/or sample fluid. The row arrangement of the electrodes is available, so that the cells associated to a row are influenceable through a flow channel formation respectively with different culture medium or different sample fluid. The surface areas are formed as gradient field. An independent claim is included for a method for the production of a sensor for electrophysiological investigation at living cells.