发明名称 |
COMPOSITIONS OF ACTIVATED BOTULINUM HOLOTOXIN TYPE B (150 KD) |
摘要 |
<p>The present invention relates to pharmaceutical compositions of activated botulinum holotoxin type B (150 kD). In particular, the present invention relates to botulinum toxin type B pharmaceutical compositions wherein at least 90% of said botulinum toxin type B is activated (i.e., "nicked"), and wherein at least 99% said nicked botulinum toxin type B is a 150 kD holotoxin (i.e., "stripped"). The invention also relates to a process of activating and stripping botulinum toxin type B wherein at least 90% of said botulinum toxin type B is nicked, and wherein at least 99% of said nicked botulinum toxin type B is stripped. The invention further relates to methods for the treatment of a variety of neuromuscular diseases, pain, inflammatory and cutaneous disorders comprising administering a pharmaceutical composition of activated botulinum holotoxin type B (150 kD) wherein at least 90% of said botulinum toxin type B is nicked, and wherein at least 99% of said nicked botulinum toxin type B is stripped.</p> |
申请公布号 |
WO2010051038(A1) |
申请公布日期 |
2010.05.06 |
申请号 |
WO2009US05942 |
申请日期 |
2009.11.03 |
申请人 |
SOLSTICE NEUROSCIENCES, INC.;GARCIA, SHERYL, ANN;MARIN, BRET;JOSEPH, SHAJI |
发明人 |
GARCIA, SHERYL, ANN;MARIN, BRET;JOSEPH, SHAJI |
分类号 |
A61K9/16 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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