METHOD FOR PRODUCING SILICA PARTICLE HAVING CROSS-LINKING FUNCTIONAL GROUP ON THE SURFACE OF THE PARTICLE, SILICA PARTICLE HAVING CROSS-LINKING FUNCTIONAL GROUP ON THE SURFACE OF THE PARTICLE, COLLOID OF THE SILICA PARTICLES, COMPOSITE PARTICLE USING THE SILICA PARTICLE, AND METHOD FOR PRODUCING THE COMPOSITE PARTICLE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing silica particles each having a cross-linking functional group, such as an isocyanate group or an epoxy group, useful for binding a biomolecule or the other to the silica particle. SOLUTION: This invention relates to the method for producing the silica particles having cross-linking functional groups on the surfaces of the particles, characterized by comprising: adding a cross-linking compound having two or more cross-linking functional groups to a silica particle dispersion dispersed in an aprotic solvent; and covalently bonding the cross-linking compound to the surfaces of the silica particles to make at least one unreacted cross-linking functional group among the two or more cross-linking functional groups exist on the surfaces of the particles. COPYRIGHT: (C)2010,JPO&INPIT