发明名称 USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR TREATING PARKINSON'S DISEASE
摘要 The present invention relates to an indole-derived compound, particularly useful in therapy, and characterized in that the compound is selected from among iii) the compounds of formula (I), where: R1 is a halogen atom or a trifluoromethyl group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is an isopropyl (1-methylethyl) group or a te/t/s-butyl (1,1-dimethylethyl), and n = 3 or 4. The invention further relates to the pharmaceutically acceptable salts of said compounds of formula (I). The invention can be used in the treatment of neurodegenerative diseases and particularly of Parkinson's disease.
申请公布号 WO2010004221(A3) 申请公布日期 2010.05.06
申请号 WO2009FR51372 申请日期 2009.07.09
申请人 LABORATOIRES FOURNIER S.A.;BOUBIA, BENAISSA;VAN VLIET, BERNARD, JOHANNES;DEN HARTOG, JACOBUS, ANTONIUS, JOSEPH;MCCREARY, ANDREW;TALLANDIER, MIREILLE;VAN DONGEN, MARIA, JOHANNA, PETRONELLA;POUPARDIN-OLIVIER, OLIVIA 发明人 BOUBIA, BENAISSA;VAN VLIET, BERNARD, JOHANNES;DEN HARTOG, JACOBUS, ANTONIUS, JOSEPH;MCCREARY, ANDREW;TALLANDIER, MIREILLE;VAN DONGEN, MARIA, JOHANNA, PETRONELLA;POUPARDIN-OLIVIER, OLIVIA
分类号 C07D209/12;A61K31/405;A61P25/16;A61P25/28;C07D209/18 主分类号 C07D209/12
代理机构 代理人
主权项
地址