摘要 |
The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d] pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
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申请人 |
MERCK SHARP & DOHME CORP.;BANYU PHARMACEUTICAL CO., LTD.;FURUKAWA, SHUNTARO;IKENO, TAKETO;KATO, SHINJI;KAWASAKI, MASASHI;KOJIMA, HISAKI;MINAGAWA, WATARU;SAWADA, NAOTAKA;YAMAMOTO, FUYUKI;LOHANI, SACHIN;WANG, YALING |
发明人 |
FURUKAWA, SHUNTARO;IKENO, TAKETO;KATO, SHINJI;KAWASAKI, MASASHI;KOJIMA, HISAKI;MINAGAWA, WATARU;SAWADA, NAOTAKA;YAMAMOTO, FUYUKI;LOHANI, SACHIN;WANG, YALING |