SEQUENCING OF NUCLEIC ACID MOLECULES BY MASS SPECTROMETRY
摘要
<p>The present invention is related to a method for determining the nucleotide sequence of a nucleic acid molecule comprising the following steps: a) providing a plurality of molecules of the nucleic acid molecule having at least one modification; b) cleaving at random the plurality of modified nucleic acid molecules thus providing modified nucleic acid molecule fragments and non-modified nucleic acid molecule fragments; c) separating the modified nucleic acid molecule fragments from the non-modified nucleic acid molecule fragments; d) separating or resolving the modified nucleic acid molecule fragments according to their length, mass and/or charge, whereby such separating or resolving generates a pattern of modified nucleic acid fragments; and e) optionally visualizing the pattern of modified nucleic acid fragments.</p>
申请公布号
WO2010049156(A1)
申请公布日期
2010.05.06
申请号
WO2009EP07754
申请日期
2009.10.29
申请人
NOXXON PHARMA AG;TURNER, JOHN;HOOS, JOHANNES;KLUSSMANN, SVEN