METHOD FOR THE FILTRATION OF A BIOREACTOR LIQUID FROM A BIOREACTOR; CROSS-FLOW MEMBRANE MODULE, AND BIOREACTOR MEMBRANE SYSTEM

摘要

The invention provides a method for the filtration of a bioreactor liquid (10) from a bioreactor (1) with a cross-flow membrane module (20) comprising one or more membranes (40). The method comprises feeding part of the bioreactor liquid (10) to a liquid inlet (21) of the cross-flow membrane module (20), transporting the bioreactor liquid (10) through the cross-flow membrane module (20) in a cross-flow mode, and removing a retentate (12) from a liquid outlet (22) of the cross-flow membrane module (20). The cross-flow membrane module (20) is arranged to allow a liquid downward flow of the bioreactor liquid (10) through the cross-flow membrane module (20). The method further comprises providing the liquid downward flow and a downward gas flow of a gas (30) through the cross-flow membrane module (20). Fouling of the membranes is relatively good prevented or reduced in time. Further, the liquid flow may be reduced relative to conventional configurations.